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Composition: Each tablet contains : 0.5 mg or 2 mg clonazepam. Inactive ingredients: Lactose Monohydrate, Maize starch , Microcrystalline cellulose , P.V.P.XL (Crospovidone) , Magnesium Strearate , Talc Purified , Patent blue , Gelatin powder.

Properties: Clonazepam Amotril® has a direct inhibitory effect on the cortical and subcortical epileptogenic foci and prevents generalization of the convulsive activity. Thus, Amotril® has a beneficial effect on primary generalized seizures and on focal epilepsy. Clonazepam potentiates the pre and postsynaptic inhibitory action of - aminobutyric acid in the CNS. It reduces over compensatory excitation with minimal effect on other physiological neuronal activity.

Indications And Usage: All types of epilepsy and seizures.Adults: Epilepsy and focal seizures. Children: Typical and atypical absences ( Lennox Gastat Syndrome), nodding spasm, primary or secondary generalized tonic-clonic spasms. N.B.: To avoid adverse reactions at the beginning of therapy, it is essential to increase the daily dose progressively until the maintenance dose suitable to the individual patient has been reached. If several doses are required,the largest dose should be given in the evening.

Contraindications: Hypersensitivity to clonazepam Patients with myasthenia gravis

Dosage & Administration: For adults Initial dose: 1-2 mg daily. Maintenance dose: 2-4 mg daily in the evening. Dose should be adjusted according to the patient’s response and tolerance to the drug with maximal recommended daily dose of 20 mg. For children: 10 - 16 years. Initial dose: 1-2 mg daily. Maintenance dose: 1.5-3 mg daily in the evening. Instruction to patients: Keep the drug out of reach of children. store at temperature not exceeding 30° C.

Drug Interactions: Concurrent administration with other antiepileptics necessitates adjustment of dosage of both drugs to give the maximum desired effect. Use with caution with other drugs that have a depressant effect on the central nervous system since the central depressant effects are additive, e.g. barbiturates and alcohol.

How Supplied: Amotril® ; Strips of 10 tablets (0.5 mg) or (2mg) in packs of 3 strips.

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